Global Advancements in Prostate Cancer: The Role of Genetic Testing and PARP Inhibitors (2022) - English

April 13, 2022

Complimentary CME Virtual Course!


Global Advancements in Prostate Cancer: The Role of Genetic Testing and PARP Inhibitors is an exciting new global educational initiative featuring a series of four interactive, case-based, live virtual courses conducted in English, Mandarin, Portuguese, and Spanish.  For each session, a Moderator will engage two other subject matter experts in an interactive, interview-style presentation and discussion. 

Based on the documented need from the AUA Phase IV Advanced Prostate Cancer Global Needs Assessment, the AUA has produced this new series of educational offerings for urologists and the urologic care team focused on the advancements in treating patients with advanced prostate cancer.  This course will address the latest developments in advanced prostate cancer disease with a focus on patient selection and approach to genetic testing, how do DNA damage repair mutations lead to prostate carcinogenesis, poly ADP ribose polymerase (PARP) and targeting DNA repair-deficient tumors, patient outcomes, clinical trials, and AUA Clinical Guideline recommendations.

Webcasts will be made available on AUAUniversity and AUA's YouTube channel.  Additionally, the course will be released as part of AUA's podcast series. Learners will also be provided with links to access additional resources including the AUA’s clinical guidelines discussed during the virtual courses and associated patient resources.


Acknowledgements

Support provided by independent educational grants from:

  • AstraZeneca
  • Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC
  • Merck

Target Audience

  • Urologists
  • Residents

Learning Objectives

At the conclusion of this activity, participants will be able to:

  1. Review recommended criteria for genetic testing of prostate cancer patients, explain how to counsel patients about genetic testing,  and how to order and interpret these tests.
  2. Explain how mutations in DNA damage repair genes can lead to the development of aggressive prostate cancer and the implications for treatment decisions.
  3. Describe the role of the enzyme poly ADP ribose polymerase (PARP) in carcinogenesis as well as the mechanism of PARP inhibition for cancer treatment.
  4. Discuss clinical trial data assessing the efficacy of PARP inhibitors in advanced prostate cancer, including patient populations and clinical outcomes for each trial.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Non-Physician Participation
Course opens: 
03/01/2022
Course expires: 
04/13/2025
Event starts: 
04/13/2022 - 7:00pm EDT
Event ends: 
04/13/2022 - 8:00pm EDT
Rating: 
0

Welcome and Introductions

Pre-Test Questions 

Patient Selection and approach to genetic testing 

How do DNA damage repair mutations lead to prostate carcinogenesis 

Poly ADP ribose polymerase (PARP) and targeting DNA repair-deficient tumors  

Patient Outcomes/Clinical Trials/AUA Clinical Guideline Recommendations 

Post-test Questions

Q&A Session 

Global Advancements in Prostate Cancer: The Role of Genetic Testing and PARP Inhibitors (2022) - English will be held virtually on Wednesday, April 13, 2022 at 7:00 p.m. - 8:00 p.m. EST.

***Instructions***

  1. Click on the TAKE COURSE button.
  2. Click “Start” under "Live Virtual Course" in the Course Progress pane.
  3. Click on the link provided to register in advance for this webinar.
  4. After registering, you will receive a confirmation email containing information about joining the webinar. 

Education Council Disclosures

PDF iconEducation Council Disclosures_ June 2021.pdf

COI Review Work Group Disclosures

PDF iconCOI Review Work Group Disclsoures_2021.pdf

All relevant financial relationships have been mitigated. 

Faculty disclosures will be posted here prior to the start of the course.

AUA Office of Education Staff has nothing to disclose.

Course Director(s)

Todd Morgan, MD

has a financial relationship (Other) with Myriad Genetics;.
has a financial relationship (Other) with MDxHealth;.
Faculty(s)

Maria Carlo, M.D.

has no relevant financial relationships to disclose at this time.

Elisabeth Heath,

has a financial relationship (Independent contractor) with Seattle Genetics;.
has a financial relationship (Other) with Oncolys;.
has a financial relationship (Independent contractor) with Seattle Genetics;.
has a financial relationship (Other) with Agensys;.
has a financial relationship (Independent contractor) with Sanofi;.
has a financial relationship (Other) with Merck;.
has a financial relationship (Independent contractor) with Sanofi;.
has a financial relationship (Independent contractor) with Zenith;.

Brian Helfand, MD

has a financial relationship (Meeting Participant or Lecturer (Oncology)) with Blue Earth Diagnostics;.
has a financial relationship (Meeting Participant or Lecturer (Oncology)) with Ambry Genetics;.
has a financial relationship (Consultant or Advisor (Oncology)) with Blue Earth Diagnostics;.
has a financial relationship (Meeting Participant or Lecturer (Oncology)) with Exact Sciences;.
has a financial relationship (Consultant or Advisor (Oncology)) with GoPath;.
has a financial relationship (Consultant or Advisor (Oncology)) with Ambry ;.
has a financial relationship (Other (Oncology)) with Exact Sciences;.

ACCREDITATION: 

The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION: 

The American Urological Association designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

OTHER LEARNERS: 

The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.

EVIDENCE BASED CONTENT: 

It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.

AUA DISCLOSURE POLICY: 

All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider any relevant financial relationships with any commercial interest. The AUA must determine if the individual’s relationships may influence the educational content and resolve any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.

MITIGATION OF IDENTIFIED CONFLICT OF INTEREST: 

All disclosures will be reviewed by the AUA Conflict of Interest (COI) Review Work Group for identification of conflicts of interest. The AUA COI Review Work Group, working with the program directors and/or editors, will document the mechanism(s) for management and mitigation of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to mitigate conflict of interest:

  • Peer review for valid, evidence-based content of all materials associated with an educational activity by the course/program director, editor, and/or AUA COI Review Work Group.
  • Limit content to evidence with no recommendations
  • Introduction of a debate format with an unbiased moderator (point-counterpoint)
  • Inclusion of moderated panel discussion
  • Publication of a parallel or rebuttal article for an article that is felt to be biased
  • Limit equipment representatives to providing logistics and operation support only in procedural demonstrations
  • Divestiture of the relationship by faculty

OFF-LABEL OR UNAPPROVED USE OF DRUGS OR DEVICES: 

The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.


AUA PARTICIPANT INFORMATION & POLICIES

Disclaimer: The opinions and recommendations expressed by faculty, authors and other experts whose input is included in this program are their own and do not necessarily represent the viewpoint of the AUA.

Consent to Use of Photographic Images: Attendance at or participation in AUA meetings and other activities constitutes an agreement by the registrant to AUA's use and distribution (both now and in the future) of the attendee's image or voice in photographs and electronic reproductions of such meetings and activities.

Audio, Video and Photographic Equipment: The use of audio, video and other photographic recording equipment by attendees is prohibited inside AUA meeting rooms.

Reproduction Permission: Reproduction of written materials developed for this AUA course is prohibited without the written permission from individual authors and the American Urological Association.

Special Assistance/Dietary Needs: The AUA complies with the Americans with Disabilities Act §12112(a). If any participant is in need of special assistance or has any dietary restrictions, please see the registration desk.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Non-Physician Participation
Please login or register to take this course.

Registration for this Live Virtual Course is complimentary.

To join the live course:

  1. Click on the TAKE COURSE button.
  2. Click “Live Virtual Course” in the Course Progress pane.
  3. Click the link to register in advance.
  4. After registering, you will receive a confirmation email containing information about joining the webinar.

Attendee Information & Policies

AUA Anti-Harassment Policy

AUA Commitment: AUA is committed to providing a safe and productive meeting environment that fosters open dialogue and the exchange of scientific ideas and is free of harassment and discrimination. All meeting participants are expected to behave professionally and treat others with respect, follow venue rules, and alert AUA staff or security of any dangerous situations or anyone in distress.

Reporting Harassment: It is the policy of the AUA that all meeting participants will enjoy an environment free from discrimination, harassment or retaliation. Harassing or offensive behavior by meeting participants will not be tolerated. If an individual experiences or witnesses harassment, he or she should contact Janet Skorepa, AUA EVP, at jskorepa@AUAnet.org or Diane Bieri, AUA General Counsel, at dbieri@AUAnet.org or use a venue phone and ask for security if he or she feels unsafe. All complaints will be treated seriously and responded to promptly.

The AUA reserves the right to take any action deemed necessary and appropriate, including refusing or revoking the registration of any individual, without refund, as long as such refusal is consistent with applicable law and AUA policy.

Disclaimer: The opinions and recommendations expressed by faculty, authors and other experts whose input is included in this program are their own and do not necessarily represent the viewpoint of the American Urological Association (AUA).

Consent to Use of Photographic Images: Registration and attendance at or participation in AUA meetings and other activities constitutes an agreement by the registrant to AUA's use and distribution (both now and in the future) of the registrant or attendee's image or voice in photographs, videotapes, electronic reproductions, and audiotapes of such events and activities.

Audio, Video, Photographic Equipment: The use of audio, video and other photographic recording equipment by attendees is prohibited inside AUA meeting rooms.

Reproduction Permission: Reproduction of written materials developed for this AUA course is prohibited without the written permission from individual authors and the AUA.

Special Assistance/Dietary Needs: The AUA complies with the Americans with Disabilities Act §12112(a). If any participant is in need of special assistance or has any dietary restrictions, a written request should be submitted at least one month in advance. For additional assistance with your request please call 1-800-908-9414.