Evidence-Based Clinical Management of Advanced and Castration-Resistant Prostate Cancer (2018)

May 17, 2018

There is a growing need for urologists to be able to effectively manage castration-resistant prostate cancer (CRPC).  The AUA recently released its 2017 report on the educational needs of urologists in the area of CRPC. These findings show strong support for the AUA to influence key stakeholders in urology residency programs in order to increase the amount of exposure residents receive in this area. Additionally, the findings indicate that the AUA should continue to develop courses and educational materials specifically targeted at residents that covers the medical management of advanced prostate cancer.

The AUA is launching an educational initiative to focus on resident and fellow training in the area of Advanced and Castration-Resistant Prostate Cancer (CRPC). Based on the documented need for additional education in this area, the AUA in collaboration with Society of Urologic Oncology (SUO) has developed multiple educational interventions to improve the ability to care for patients with CRPC. These educational activities may also be of interest to advanced practice providers and urologists.

The 2018 series is comprised of a variety of activities, including two live forums, four live webinars, webcasts and podcasts.

All activities are complimentary.


This educational series is supported by independent educational grants from:

  • Astellas and Pfizer Inc.
  • Ferring Pharmaceuticals Inc.
  • Genomic Health
  • Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC
  • Sanofi Genzyme
  • Tolmar Pharmaceuticals, Inc.

Target Audience

  • Residents
  • Fellows
  • Advanced practice providers
  • This activity may also be of interest to urologists and other health care providers who care for patients with prostate cancer

Learning Objectives

At the conclusion of this activity, participants will be able to:  

Practice Gap #1 (Disease State)

  1. Describe the natural course of advanced prostate cancer from non-metastatic to metastatic hormone-sensitive disease, with progression to the development of castration-resistant disease.
  2. Describe the treatment options and outcomes for newly diagnosed metastatic hormone-sensitive prostate cancer.
  3. Explain the implications of CRPC on the management of both M0 and M1.
  4. Discuss the molecular mechanisms and characterization of CRPC.

Practice Gap #2 (Guidelines)

  1. Discuss specific recommendations within the AUA Clinical Practice Guidelines.
  2. Define M0 CRPC and the treatment options.
  3. Discuss clinically meaningful endpoints in clinical trials of patients with MO CRPC.
  4. Describe gaps in the knowledge for treatment and sequencing of agents in the management of CRPC.

Practice Gap #3 (Androgen Axis)

  1. Identify approved androgen biosynthesis and receptor blockers for treatment of CRPC.
  2. Appraise the clinical use and efficacy of approved androgen-axis therapeutics for CRPC.
  3. Anticipate, manage and treat adverse events from therapeutic interventions directed at the androgen-axis used in the treatment of CRPC.
  4. Discuss new uses for androgen axis agents in M0 CRPC.

Practice Gap #4 (Chemotherapy, Immunotherapy and Co-Morbidity)

  1. Identify approved chemotherapeutics and immunotherapy for mCRPC.
  2. Describe indications and contraindications for chemotherapy and immunotherapy in patients with mCRPC.
  3. Identify co-morbid states and recognize their impact on treatment options for mCRPC.
  4. Discuss treatment sequencing.

Practice Gap #5 (Bone Health and Radionuclide Therapy)

  1. Integrate advances in bone health management into patient-specific care plans.
  2. Identify patients and prescribe radionuclide therapy in appropriate patients with symptomatic mCRPC.

Practice Gap #6 (Pain Management and Palliative Care)

  1. Assess and manage pain in patients with CRPC.
  2. Discuss the role of chemotherapy, performance status and pain management in patients with mCRPC.
Course summary
Available credit: 
  • 5.25 AMA PRA Category 1 Credit™
  • 5.25 Non-Physician Participation
Course opens: 
Course expires: 
Event starts: 
05/17/2018 - 10:00am EDT
Event ends: 
05/17/2018 - 5:00pm EDT

9:00 – 10:00 a.m.                 Registration & Refreshments

10:00 – 10:10 a.m.               Welcome - Victor W. Nitti, MD, Michael S. Cookson, MD, MMHC & David F. Jarrard, MD              

10:10 – 10:25 a.m.               Pre-Test - Michael S. Cookson, MD, MMHC & David F. Jarrard, MD


Session I

10:25 – 10:45 a.m.               Initial Management and Imaging of Advanced Prostate Cancer - Todd Matthew Morgan, MD

10:45 – 11:05 a.m.               Chemo-hormonal Therapy for Metastatic Hormone Sensitive Prostate Cancer - Alicia Morgans, MD, MPH

11:05 – 11:25 a.m.               M0 CRPC: Emerging Treatment Options - Alicia Morgans, MD, MPH

11:25 – 11:45 a.m.               MDC and Review of CRPC Guidelines - Michael S. Cookson, MD, FACS

11:45 a.m. – 12:15 p.m.       Case Based Roundtable Discussions - Session I - All Faculty  

12:15 – 12:20 p.m.               Session I Post-Test - Michael S. Cookson, MD, MMHC & David F. Jarrard, MD

12:20 – 1:35 p.m.                 "Elevate Care in Advanced Prostate Cancer"

                                             A Non-CME Lunch Symposium supported by Astellas Pharma US, Inc.


Session II

1:35 – 1:55 p.m.                   Manipulating the Androgen Axis:  Androgen Biosynthesis Inhibitors and Androgen Receptor Signaling Agents - 

                                             David F. Jarrard, MD, FACS

1:55 – 2:15 p.m.                   Radionuclide Therapy and Bone Health - Kelly L. Stratton, MD

2:15 – 2:45 p.m.                   Case Based Roundtable Discussions – Session II - All Faculty  

2:45 – 2:50 p.m.                   Session II Post-Test - Michael S. Cookson, MD, MMHC & David F. Jarrard, MD

2:50 – 3:10 p.m.                   Break


Session III

3:10– 3:40 p.m.                    Role of Chemotherapy and Performance Status and Pain Management - Robert Dreicer, MD

3:40– 4:00 p.m.                    Treatment Sequencing, Immunotherapy and Future Approaches - Kelly L. Stratton, MD

4:00 – 4:40 p.m.                   Case Based Roundtable Discussions - Session III - All Faculty

4:40 – 4:45 p.m.                   Session III Post-Test - Michael S. Cookson, MD, MMHC & David F. Jarrard, MD

4:45 – 5:00 p.m.                   Closing Remarks - Michael S. Cookson, MD, MMHC & David F. Jarrard, MD


Moscone Convention Center West
747 Howard St
San Francisco, CA
United States
+1 (415) 974-4000


For your convenience, we recommend that live forum attendees book their stay through our official AUA2018 housing partner OnPeak. The AUA's APP Designated Hotels are the Parc 55 Hotel and Hotel Union Square.




The AUA will not be providing shuttle service to the course at the Convention Center on Thursday, May 17. Shuttle service will begin on Friday, May 18, the first day of the AUA Annual Meeting. Attendees can find transportation information and resources on the AUA2018 Website.

Car Rental

Hertz is pleased to offer special discounted car rental rates to AUA course and meeting attendees. Make your car rental reservation online or call 1-800-654-2240 and mention the AUA discount code CV# 04SG0003.


The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The American Urological Association designates this live activity for a maximum of 5.25 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Other Learners

The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 CreditTM.

Evidence-Based Content

It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous and free of commercial bias.

AUA Disclosure Policy

All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) participating in an educational activity provided by the AUA are required to disclose to the provider any relevant financial relationships with any commercial interest. The AUA must determine if the individual's relationships may influence the educational content and resolve any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.

Resolution of Identified Conflict of Interest

All disclosures will be reviewed by the program/course directors or editors for identification of conflicts of interest. Peer reviewers, working with the program directors and/or editors, will document the mechanism(s) for management and resolution of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to resolve conflict of interest:

  • Peer review for valid, evidence-based content of all materials associated with an educational activity by the course/program director, editor and/or Education Content Review Committee or its subgroup.

  • Limit content to evidence with no recommendations

  • Introduction of a debate format with an unbiased moderator (point-counterpoint)

  • Inclusion of moderated panel discussion

  • Publication of a parallel or rebuttal article for an article that is felt to be biased

  • Limit equipment representatives to providing logistics and operation support only in procedural demonstration.

  • Divestiture of the relationship by faculty

Off-label or Unapproved Use of Drugs or Devices

The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.

Available Credit

  • 5.25 AMA PRA Category 1 Credit™
  • 5.25 Non-Physician Participation
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