Practical Management of Metastatic Prostate Cancer: Guidelines and Beyond - Los Angeles (2017)
Urologists continue to indicate one of the greatest educational needs in treating CRPC patients is the sequencing of agents. With the numerous new treatments now available to urologists to manage the CRPC patient, sequencing and managing the side effects of each treatment have become increasingly important. In addition, studies are demonstrating that earlier treatment with these systemic agents has improved efficacy. Urologists play a central role in the management of metastatic and castrate resistant prostate cancer and as their role continues to increase, knowledge of the various side effects of the numerous treatments that are available is paramount.
This course will provide essential information on the role of systemic therapy in the treatment of metastatic prostate cancer, focusing upon a thorough review of the AUA CRPC Guidelines, followed by management of castrate sensitive prostate cancer with systemic agents, sequencing of agents, managing side effects of treatments, management of comorbid conditions, and identifying potential interactions between agents. Additionally, the course will include a section on pain management and training on counseling/support of patients in end-of-life issues.
Target Audience
- APN/PA
- Non-Urologist MD
- Nurse
- Urologist
Learning Objectives
At the end of the course, attendees will be able to:
- Apply the AUA CRPC Guidelines for FDA approved agents in the management of CRPC and optimization of the AUA algorithm for patient clinical benefit.
- Evaluate and diagnose CRPC patients and discuss the sequencing and combinatorial treatment strategies from both clinical and administrative perspectives.
- Analyze the role of systemic agents in androgen sensitive metastatic prostate cancer.
- Examine the side effect profiles and potential interactions of various therapeutic strategies for CRPC.
- Oversee comorbid conditions and describe their management in the context of CRPC treatment.
- Manage both the acute and chronic pain that is inherent in the care of CRPC patients.
- Communicate the pertinent end-of-life issues that surround CRPC patients and their families.
7:00 – 8:00 am Registration & Continental Breakfast
8:00 – 8:15 am Welcome & Introduction
Adam S. Kibel, MD
8:15 – 8:30 am Pre-Test
Adam S. Kibel, MD
Session I: Guidelines and Treatment Strategies
8:30 – 9:15 am Overview of AUA CRPC Guidelines for FDA Approved Agents in the Management of CRPC
Adam S. Kibel, MD
9:15 – 10:00 am Treatment Sequencing and Combinatorial Strategies in CRPC
Tanya B. Dorff, MD
10:00 – 10:05 am Session I Post- Test
Tanya B. Dorff, MD
10:05 – 10:20 am Break
Session II: Side Effect Management and Toxicities of Therapy
10:20 – 11:05 am Comorbidities and Side Effect Profiles – Considerations for Various CRPC Therapeutic Strategies
Evan Y. Yu, MD
11:05 – 11:50 am Future Directions in Systemic Therapy
Evan Y. Yu, MD
11:50 – 12:35 pm Bone Health and Management of Toxicities of Therapy in the Context of CRPC Treatment
Robert E. Reiter, MD
12:35 –12:40 pm Session II Post- Test
Robert E. Reiter, MD
12:40 – 1:50 pm Lunch
A Non-CME Lunch Symposium supported by Astellas Pharma US, Inc. and Pfizer Oncology
Session III: Practical Management of a CRPC Clinic
1:50 – 2:20 pm Practical Guide to an Advanced Prostate Cancer Clinic
Lawrence I. Karsh, MD
2:20 – 2:50 pm Panel Discussion
All Faculty, Moderator: Lawrence I. Karsh, MD
Session IV: Quality and End-of Life Issues in CRPC
2:50 – 3:20 pm Acute and Chronic Pain Management in CRPC
Edouard J. Trabulsi, MD
3:20 – 3:50 pm End-of-life Issues in CRPC Patients and Their Families
Tanya B. Dorff, MD
3:50 – 3:55 pm Session IV Post-Test
Tanya B. Dorff, MD
3:55 – 4:10 pm Break
Session V: Revisiting the Index Patients with a New Perspective
4:10 – 4:50 pm Case Study 1 & 2
Round Table Case Discussions
Questions and Review of Cases
Lawrence I. Karsh, MD & Tanya B. Dorff, MD
4:50 – 5:30 pm Case Study 3 & 4
Round Table Case Discussions
Questions and Review of Cases
Edouard J. Trabulsi, MD & Robert E. Reiter, MD
5:30 pm Course Adjourn
Name | Company | Role | Financial |
Tanya B. Dorff, MD | Bayer | Meeting Participant or Lecturer, Scientific Study or Trial | Yes |
Exelixis | Meeting Participant or Lecturer | Yes | |
Pfizer | Consultant or Advisor, Meeting Participant or Lecturer | Yes | |
Lawrence I. Karsh,MD | Astellas | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes |
Dendreon | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Bayer | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Janssen | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Medivation | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Genomic Health | Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Myriad | Consultant or Advisor, Scientific Study or Trial | Yes | |
Swan Valley Medical | Consultant or Advisor, Investment Interest | Yes | |
Amgen | Scientific Study or Trial | Yes | |
Heat Biologics | Scientific Study or Trial | Yes | |
Bavaria Nordic Immunotherapy | Consultant or Advisor, Scientific Study or Trial | Yes | |
MDxHealth | Scientific Study or Trial | Yes | |
Lawrence Karsh | Health Publishing, Consultant or Advisor, Meeting Participant or Lecturer, Scientific Study or Trial, Investment Interest | Yes | |
Spectrum Pharmaceuticals | Consultant or Advisor, Scientific Study or Trial | Yes | |
FKD | Scientific Study or Trial | Yes | |
Pfizer | Consultant or Advisor | Yes | |
Sanofi | Consultant or Advisor | Yes | |
Tolmar | Consultant or Advisor | Yes | |
Ferring | Consultant or Advisor | Yes | |
Abbvie | Consultant or Advisor | Yes | |
Argos | Consultant or Advisor, Scientific Study or Trial | Yes | |
Astra-Zeneca | Consultant or Advisor | Yes | |
Augmenix | Consultant or Advisor, Scientific Study or Trial | Yes | |
Precision Biopsy | Consultant or Advisor, Scientific Study or Trial | Yes | |
Takeda | Consultant or Advisor, Scientific Study or Trial | Yes | |
Tokai | Consultant or Advisor, Scientific Study or Trial | Yes | |
3D BIopsy | Consultant or Advisor, Scientific Study or Trial | Yes | |
GenomeDx BIosciences | Consultant or Advisor, Scientific Study or Trial | Yes | |
Precision Med | Scientific Study or Trial | Yes | |
Adam S. Kibel, MD | Sanofi-Aventis | Consultant or Advisor, Scientific Study or Trial | Yes |
MTG | Consultant or Advisor | Yes | |
Profound | Consultant or Advisor | Yes | |
Dendreon | Consultant or Advisor | Yes | |
Alicia K. Morgans, MD, MPH | AstraZeneca | Consultant or Advisor | Yes |
Robert E. Reiter, MD | ImaginAb Corporation | Investment Interest | Yes |
Charles J. Ryan, MD | Johnson and Johnson | Consultant or Advisor | Yes |
| Scientific Study or Trial | Yes | |
Millennium | Consultant or Advisor | Yes | |
Janssen | Meeting Participant or Lecturer | Yes | |
Bayer | Consultant or Advisor | Yes | |
Ferring | Consultant or Advisor | Yes | |
Xcell Biosciences | Other : Equity | Yes | |
Astellas | Meeting Participant or Lecturer | Yes | |
AstraZeneca | Consultant or Advisor | Yes | |
Karyopharm | Scientific Study or Trial | Yes | |
Kelly L. Stratton, MD | Ebix | Other : Contributor | Yes |
Bayer Corporation | Consultant or Advisor | Yes | |
MDXHealth | Consultant or Advisor | Yes | |
Oakstone | Other : Professional Service | Yes | |
Edouard J. Trabulsi, MD |
| Consultant or Advisor | Yes |
Evan Y. Yu, MD | Agensys | Consultant or Advisor, Scientific Study or Trial | Yes |
Genentech | Meeting Participant or Lecturer, Scientific Study or Trial | Yes | |
Bayer | Scientific Study or Trial | Yes | |
| Consultant or Advisor | Yes | |
Merck | Scientific Study or Trial | Yes | |
Astellas | Consultant or Advisor, Scientific Study or Trial | Yes | |
Janssen | Consultant or Advisor | Yes | |
Merck | Consultant or Advisor | Yes | |
Voluntis | Consultant or Advisor | Yes |
Accreditation: The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation: The American Urological Association designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other Learners: The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.
Evidence Based Content: It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.
AUA Disclosure Policy: All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider any relevant financial relationships with any commercial interest. The AUA must determine if the individual’s relationships may influence the educational content and resolve any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.
Resolution of Identified Conflict of Interest: All disclosures will be reviewed by the program/course directors or editors for identification of conflicts of interest. Peer reviewers, working with the program directors and/or editors, will document the mechanism(s) for management and resolution of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to resolve conflict of interest:
- Peer review for valid, evidence-based content of all materials associated with an educational activity by the course/program director, editor, and/or Education Content Review Committee or its subgroup.
- Limit content to evidence with no recommendations
- Introduction of a debate format with an unbiased moderator (point-counterpoint)
- Inclusion of moderated panel discussion
- Publication of a parallel or rebuttal article for an article that is felt to be biased
- Limit equipment representatives to providing logistics and operation support only in procedural demonstrations
- Divestiture of the relationship by faculty
Available Credit
- 7.75 AMA PRA Category 1 Credit™
- 7.75 Non-Physician Participation