The Evolving Landscape of Advanced Prostate Cancer Treatment: A Guidelines and Case-Based Discussion (2022)

New Orleans, LA US
May 12, 2022

Presented by the AUA in partnership with the Society of Urologic Oncology (SUO).

SUO strongly encourages that fellows participate in at least one SUO-sponsored educational course as available during their fellowship in addition to attending the Annual/Winter Meeting and the AUA/Spring Meeting. This educational course satisfies this recommendation.

Complimentary CME Course! 

Thursday, May 12, 2022 | 8:30 a.m. - 4 p.m. Central Time

Join Course Directors, Michael S. Cookson, MD, MMHC, FACS & David F. Jarrard, MD for an educational initiative in advanced prostate cancer.

As a direct result of the significant increase in multiple FDA-approved therapeutic agents for use in patients with advanced prostate cancer, clinicians are challenged with a multitude of treatment options and potential sequencing of these agents that, consequently, make clinical decision-making more complex. This activity will build upon the updated 2020 AUA Guidelines on Metastatic Hormone Sensitive Prostate Cancer (HSPC) and Castration-Resistant Prostate Cancer (CRPC). Topics will include the latest on Genetic Testing in Advanced Prostate Cancer and the Role of Immunotherapy and PARP Inhibitors. 

Designed for residents, fellows and APPs as well as urologists and other health care providers who care for patients with prostate cancer, this interactive forum will focus on the application of knowledge with case studies and small group discussion integrated throughout the day. A flipped classroom approach will be utilized. Register early to receive the Prework Library which will be available to all registered participants in March 2022. Participants will be expected to complete the Prework Library in advance of attending the live course - complete the prework on your own time, at your convenience. Then, come prepared on May 12 to actively engage with peers as you apply what you've learned.

Pre-registration is required as space is limited.

Needs assessment findings show strong support for continued development of courses and educational materials specifically targeted at residents and fellows that cover the medical management of advanced prostate cancer. This activity may also be of interest to urologists and other health care providers who care for patients with prostate cancer.

The Live Forum will cover the following topics*:

  • Identification of High Risk Disease and Initial Management of Biochemical Recurrence
  • Imaging of Advanced Prostate Cancer
  • M0 CRPC: Treatment Options and Goals of Therapy
  • Manipulating the Androgen Axis: New Agents in mHSPC and CRPC
  • Genetic Testing in Advanced Prostate Cancer
  • Bone Health and Radionuclide Therapy 
  • Role of Immunotherapy and PARP Inhibitors
  • Role of Chemotherapy, Treatment Sequencing in mCRPC and Future Directions

*Visit the program tab for full details.

Acknowledgements

This educational activity is supported by independent educational grants from:

  • Astellas
  • AstraZeneca
  • Bayer HealthCare Pharmaceuticals Inc.
  • Exact Sciences Corporation
  • Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC
  • Lantheus Medical Imaging
  • Pfizer, Inc.
  • Sanofi Genzyme

Target Audience

  • Urologist
  • Resident
  • Fellow
  • Advanced Practice Provider (Nurse Practitioners & Physician Assistants)

Learning Objectives

At the conclusion of this activity, participants will be able to:  

PRACTICE GAP #1 (DISEASE STATE)

  1. Describe the natural course of advanced prostate cancer from non-metastatic (M0) to metastatic hormone-sensitive disease (mHSPC), with progression to the development of castration-resistant disease (CRPC).
  2. Describe the treatment options and outcomes for patients with biochemical recurrence after failed local therapy.
  3. Identify available imaging and indications for use including next generation PET imaging in the assessment of men with biochemical recurrence after failed local therapy.
  4. Describe the treatment options and outcomes for newly diagnosed mHSPC.
  5. Explain the implications of CRPC on the management of both M0 and M1.
  6. Discuss the molecular mechanisms and characterization of CRPC.
  7. Discuss the incorporation of genetic testing (both germline and somatic testing) into the management of men with high risk, metastatic prostate cancer and CRPC.

PRACTICE GAP #2 (GUIDELINES)

  1. Discuss specific recommendations within the AUA Clinical Practice Guidelines.
  2. Define M0 CRPC and the treatment options.
  3. Discuss clinically meaningful endpoints in clinical trials of patients with M0 CRPC.
  4. Describe gaps in the knowledge for treatment and sequencing of agents in the management of CRPC.
  5. Discuss challenges in incorporating AUA Guidelines and management of advanced mHSPC and CRPC into community practice.

PRACTICE GAP #3 (ANDROGEN AXIS)

  1. Identify approved androgen biosynthesis and receptor blockers for treatment of CRPC.
  2. Appraise the clinical use and efficacy of approved androgen-axis therapeutics for CRPC.
  3. Anticipate, manage and treat adverse events from therapeutic interventions directed at the androgen-axis used in the treatment of CRPC.
  4. Discuss new uses for androgen axis agents in M0 CRPC.

PRACTICE GAP #4 (CHEMOTHERAPY, IMMUNOTHERAPY, PARP INHIBITORS AND CO-MORBIDITY)

  1. Identify approved chemotherapeutics, immunotherapy and PARP Inhibitors for mCRPC.
  2. Describe indications and contraindications for chemotherapy, immunotherapy and PARP Inhibitors in patients with mCRPC.
  3. Identify co-morbid states and recognize their impact on treatment options for mCRPC.
  4. Identify germline and somatic mutations and implications for treatment in mCRPC including indications for PAPR Inhibitors and pembrolizumab.
  5. Discuss treatment sequencing in the advanced, metastatic and CRPC disease state.

PRACTICE GAP #5 (BONE HEALTH AND RADIONUCLIDE THERAPY)

  1. Integrate advances in bone health management into patient-specific care plans.
  2. Identify patients and prescribe radionuclide therapy in appropriate patients with symptomatic mCRPC.
  3. Discuss known adverse events associated with androgen biosynthesis inhibitors and radionuclide therapy.

PRACTICE GAP #6 (PAIN MANAGEMENT AND PALLIATIVE CARE)

  1. Assess and manage pain in patients with symptomatic mHSPC and mCRPC.
  2. Discuss the role of chemotherapy, performance status and pain management in patients with mCRPC.
  3. Review the role of palliative care and supportive services in the management of late stage CRPC.
Course summary
Available credit: 
  • 5.75 AMA PRA Category 1 Credit™
  • 5.75 Non-Physician Participation
Course opens: 
01/24/2022
Course expires: 
05/12/2025
Event starts: 
05/12/2022 - 12:00pm EDT
Event ends: 
05/12/2022 - 5:00pm EDT
Add to calendar: 
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Thursday, May 12, 2022

All times are listed in Central Time

Agenda
8:30 — 8:35 a.m.

Welcome
Jay D. Raman, MD, FACS, AUA Chair, Office of Education

Michael S. Cookson, MD, MMHC & David F. Jarrard, MD

8:35 — 8:45 a.m.Pre-Test
Michael S. Cookson, MD, MMHC & David F. Jarrard, MD
Session I
8:45 — 9:05 a.m.Identification of High-Risk Disease and Initial Management of Biochemical Recurrence
Stephen A. Boorjian, MD
9:05 — 9:25 a.m.Imaging of Advanced Prostate Cancer and Impact on Cancer Management
Kelly L. Stratton, MD
9:25 — 9:40 a.m.M0 CRPC: Treatment Options and Goals of Therapy
Michael S. Cookson, MD, MMHC
9:40 — 10:30 a.m.Case-based Roundtable Discussions: Recurrent and Nonmetastatic CRPC
  • Case #1 –BCR & Novel PET Imaging– Stephen A. Boorjian, MD
  • Case #2 – M0 CRPC – Michael S. Cookson, MD, MMHC

Roundtable Discussants: All Faculty
10:30 — 10:45 a.m.Break
10:45 — 11:05 a.m.Manipulating the Androgen Axis: New Agents in mHSPC and CRPC
David F. Jarrard, MD
11:05 — 11:25 a.m.Genetic Testing in Advanced Prostate Cancer
Leonard Gomella, MD, FACS
11:25 — 11:45 a.m.mHSPC: Maximal Androgen Targeted vs Chemohormonal Therapy for mHSPC and Management of Oligometastatic Disease
David F. Jarrard, MD & Joshua M. Lang, MD
11:45 a.m. — 1:00 p.m.A Non-CME Lunch Symposium supported by Exact Sciences Corporation
Session II
1:00 — 1:20 p.m.Bone Health and Radionuclide Therapy
Stephen A. Boorjian, MD
1:20 — 1:40 p.m.Role of Immunotherapy and PARP Inhibitors
Alicia Morgans, MD, MPH
1:40 — 2:30 p.m.Case-based Roundtable Discussions: Chemotherapy-naïve Metastatic CRPC
  • Case #3 - Early M1 CRPC (Docetaxel vs. AR vs. Sipleucel-T) – Kelly L. Stratton, MD
  • Case #4 - Advanced M1 CRPC (Docetaxel and Ra-223) – Alicia Morgans, MD, MPH

Roundtable Discussants: All Faculty
2:30 — 2:45 p.m.Break
Session III
2:45 — 3:10 p.m.Role of Chemotherapy, Treatment Sequencing in mCRPC and Future Directions
Joshua M. Lang, MD
3:10 — 4:00 p.m.Case-based Roundtable Discussions: Post-Chemotherapy Metastatic CRPC
  • Case #5 - Role of Genetic Testing in Advanced M1 CRPC (Immunotherapy or PARP Inhibitors) – Leonard Gomella, MD, FACS
  • Case #6 - M1 CRPC Post-docetaxel, Neuroendocrine Cancer and End-of-Life Care – Joshua M. Lang, MD

Roundtable Discussants: All Faculty
4:00 p.m.Adjourns
Michael S. Cookson, MD, MMHC & David F. Jarrard, MD
New Orleans Ernest N. Morial Convention Center
900 Convention Center Boulevard
New Orleans, LA 70130
United States

Travel

The AUA recommends that you register for the course BEFORE making travel arrangements. Once the meeting capacity is reached, the AUA is unable to guarantee a spot in the course.

In partnership with onPeak, AUA has secured discounted rates at a selection of New Orleans hotels. Through onPeak, AUA is able to offer you convenient and affordable options for your trip to AUA2022 Annual Meeting. Visit AUA2022.org for more information.

AUA COVID-19 Safety Policies

AUA’s goal is to host a safe and meaningful Annual Meeting. As such, this course will follow all health and safety measures of the AUA’s Annual Meeting.  All AUA2022 in-person attendees, exhibitors, vendors, and guests must be fully vaccinated against COVID-19 or provide negative test results taken 72-hours or less from the time of entry in order to gain access to the Ernest N. Morial Convention Center.

Please visit https://www.auanet.org/annualmeeting/health-and-safety for more information and check back for news and additional guidance as the page is updated regularly.

Faculty Disclosures

PDF icon Faculty Disclosures

Education Council Disclosures

PDF icon Education Council Disclosures

COI Review Work Group Disclosures

PDF icon COI Review Work Group Disclosures

 

AUA Office of Education Staff has nothing to disclose.

All relevant financial relationships have been mitigated.

Accreditation: The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation: The American Urological Association designates this live activity for a maximum of 5.75 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Learners: The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.

Evidence Based Content: It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.

AUA Disclosure Policy: All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider all financial relationships with any commercial interest during the previous 24 months. The AUA must determine if the individual’s relationships may influence the educational content and mitigate any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.

Mitigation of Identified Conflict of Interest: All disclosures will be reviewed by the AUA Conflict of Interest (COI) Review Work Group Chair and/or Vice Chair for identification of conflicts of interest. The AUA COI Review Work Group, working with Office of Education staff, will document the mechanism(s) for management and mitigation of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to mitigate conflict of interest:

  • Peer review for valid, evidence-based content by the AUA COI Review Work Group.
  • Attestation that clinical recommendations are evidence-based and free of commercial bias.
  • Introduction of a debate format (point-counterpoint)
  • Inclusion of moderated panel discussion with unbiased moderator
  • Publication of a parallel or rebuttal article for an article that is felt to be biased
  • Divestiture of the relationship by faculty
  • Recusal from controlling relevant aspects of planning
  • Selection of alternative faculty for specific topic

Off-label or Unapproved Use of Drugs or Devices: The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.

Available Credit

  • 5.75 AMA PRA Category 1 Credit™
  • 5.75 Non-Physician Participation
Please login or register to take this course.

Registration for this course is complimentary; however should you need to cancel your participation for any reason, please let us know at least two weeks before the course by contacting education@auanet.org. 

Attendee Information & Policies 

AUA Anti-Harassment Policy 

AUA Commitment: AUA is committed to providing a safe and productive meeting environment that fosters open dialogue and the exchange of scientific ideas and is free of harassment and discrimination. All meeting participants are expected to behave professionally and treat others with respect, follow venue rules, and alert AUA staff or security of any dangerous situations or anyone in distress. 

Reporting Harassment: It is the policy of the AUA that all meeting participants will enjoy an environment free from discrimination, harassment or retaliation. Harassing or offensive behavior by meeting participants will not be tolerated. If an individual experiences or witnesses harassment, he or she should contact Janet Skorepa, AUA EVP, at jskorepa@AUAnet.org or Diane Bieri, AUA General Counsel, at dbieri@AUAnet.org or use a venue phone and ask for security if he or she feels unsafe. All complaints will be treated seriously and responded to promptly. 

The AUA reserves the right to take any action deemed necessary and appropriate, including refusing or revoking the registration of any individual, without refund, as long as such refusal is consistent with applicable law and AUA policy. 

Disclaimer: The opinions and recommendations expressed by faculty, authors and other experts whose input is included in this program are their own and do not necessarily represent the viewpoint of the American Urological Association (AUA). 

Consent to Use of Photographic Images: Registration and attendance at or participation in AUA meetings and other activities constitutes an agreement by the registrant to AUA's use and distribution (both now and in the future) of the registrant or attendee's image or voice in photographs, videotapes, electronic reproductions, and audiotapes of such events and activities. 

Audio, Video, Photographic Equipment: The use of audio, video and other photographic recording equipment by attendees is prohibited inside AUA meeting rooms. 

Reproduction Permission: Reproduction of written materials developed for this AUA course is prohibited without the written permission from individual authors and the AUA. 

Special Assistance/Dietary Needs: The AUA complies with the Americans with Disabilities Act §12112(a). If any participant is in need of special assistance or has any dietary restrictions, a written request should be submitted at least one month in advance. For additional assistance with your request please call 1-800-908-9414. 

AUA COVID-19 Safety Policies

AUA’s goal is to host a safe and meaningful Annual Meeting. As such, this course will follow all health and safety measures of the AUA’s Annual Meeting.  All AUA2022 in-person attendees, exhibitors, vendors, and guests must be fully vaccinated against COVID-19 or provide negative test results taken 72-hours or less from the time of entry in order to gain access to the Ernest N. Morial Convention Center.

Please visit https://www.auanet.org/annualmeeting/health-and-safety for more information and check back for news and additional guidance as the page is updated regularly.