Genetics and Genomics of GU Malignancies: Applications into Your Clinical Practice Webcast (2023)

This case-based interactive course reviews the role of germline genetics in genitourinary (GU) cancers and how the identification of an alteration may impact precision oncology. We will provide a concise and comprehensive review of hereditary cancer genetics, and discuss genetic risk assessment, diagnosis and treatment for a range of hereditary kidney, urothelial carcinoma, prostate, and adrenal cancer syndromes. We will review current National Comprehensive Cancer Network® Guidelines for genetic evaluation of patients with kidney, upper tract, prostate, and adrenal cancers. Additional areas of focus include genetic and genomic testing technologies, interpretation of genetics and genomics test results, genetics counseling and informed consent for genetic testing. Participants will learn how to integrate genetic evaluation into their clinical practice and cancer survivorship clinic, especially in areas where clinical genetics service is not readily available.


Independent educational grant support provided by:

  • Astellas
  • AstraZeneca
  • Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC
  • Lantheus Medical Imaging
  • Merck & Co., Inc.
  • Pfizer, Inc.

Learning Objectives

At the conclusion of this activity, participants will be able to:

  1. Describe the genetic basis of cancer susceptibility and development. Understand the difference between and genetics and genomics.
  2. Review indications for germline genetic testing in patients with kidney, upper tract, prostate, and adrenal cancers.
  3. Assess the goals and impact of genetic testing in patients with GU cancers and implications for family members of patients with a pathogenic germline variant.
  4. Recognize genetic causes, tumor features and cancer risk associated with GU cancer predisposition syndromes such as Lynch and hereditary kidney cancer syndromes, and apply gained knowledge to improve care of patients.
  5. Describe critical components of genetic risk assessment and informed consent for genetic testing.
Course summary
Available credit: 
  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Non-Physician Participation
Course opens: 
Course expires: 


NameCompany NameRelationship TypeEnd Date
William L. Lowrance, MDNone  
Leonard G. Gomella, MDMerck ManualHealth PublishingCurrent
 MDx HealthConsultant or AdvisorCurrent
 Merck PharmaceuticalsConsultant or AdvisorCurrent
 Astra ZenecaConsultant or AdvisorCurrent
 ExelixisConsultant or AdvisorCurrent
 LantheusConsultant or AdvisorCurrent
Heather Cheng, MD, PhDNone  



PDF icon Education Council Disclosures_2022.pdf


PDF iconCOI Review Work Group Disclosures_2023_0.pdf


AUA Office of Education Staff has nothing to disclose.

All relevant financial relationships have been mitigated.


Learners will participate in this online educational activity by view the webcast and completing the post-test and evaluation. To claim CME credit for this enduring material, learners must complete the post-test, passing with 80% accuracy, and submit the program evaluation.

Estimated time to complete this activity: 2.00 hours

Release Date: May, 2023
Expiration Date: May, 2024


The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


The American Urological Association designates this enduring material for a maximum of 2.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.


It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.


All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider all financial relationships with any commercial interest (aka ineligible company) during the previous 24 months. The AUA must determine if the individual’s relationships may influence the educational content and mitigate any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.


All disclosures will be reviewed by the AUA Conflict of Interest (COI) Review Work Group Chair and/or Vice Chair for identification of conflicts of interest. The AUA COI Review Work Group, working with Office of Education staff, will document the mechanism(s) for management and mitigation of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to mitigate conflict of interest:

  • Peer review for valid, evidence-based content by the AUA COI Review Work Group.
  • Attestation that clinical recommendations are evidence-based and free of commercial bias.
  • Introduction of a debate format (point-counterpoint)
  • Inclusion of moderated panel discussion with unbiased moderator
  • Publication of a parallel or rebuttal article for an article that is felt to be biased
  • Divestiture of the relationship by faculty
  • Recusal from controlling relevant aspects of planning
  • Selection of alternative faculty for specific topic


The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.

Available Credit

  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Non-Physician Participation
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