AUA Guidelines on Advanced/Metastatic/Castration Resistant Prostate Cancer Webcast (2021)

This course will review the important and newly updated 2020 AUA Guidelines on Metastatic Hormone Sensitive (HSPC) and Castration-Resistant Prostate Cancer (CRPC). This includes a thorough discussion of new trials and approval of agents directed at the androgen axis for treatment of M1 HSPC and non-metastatic MO CRPC. Faculty will highlight the management of patients with advanced prostate cancer, including mHSPC, nmCRPC, and CRPC, and how therapeutic options have been incorporated into evidence-based guidelines. Also, the role of genetic testing (germline and somatic) in the evaluation of M1HSPC and CRPC, as well as discuss new developments and future research needs for this topic. The course will showcase clinical scenarios in urological practice and the correct application of the new AUA Advanced, Metastatic and CRPC guidelines in those instances. This course will be a benefit to practicing urologists, oncologists, advanced practice providers, as well as residents/fellows and clinicians preparing for their certification and re-certification exams, respectively.


Independent educational grant support provided by: 

  • Amgen
  • Astellas
  • AstraZeneca
  • Bristol-Myers Squibb
  • Exact Sciences Corporation
  • Janssen Biotech, Inc. Administered by Janssen Scientific Affairs, LLC
  • Merck
  • Pfizer, Inc.
  • Sanofi Genzyme   

Target Audience

  • Urologists
  • Residents
  • Advanced Practice Providers (Nurse Practitioners and Physician Assistants)

Learning Objectives

At the conclusion of this course, participants will be able to:

  1. Identify the active agents and their mechanism of action in the management of nmCRPC and mCRPC
  2. Describe sequencing and indications for active treatment with approved agents in the management of nmCRPC
  3. Analyze the evidence and outcomes on the treatment of MO and M1 CRPC as outlined in the newly updated AUA CRPC guidelines
  4. Improve diagnostic and therapeutic decision making processes by illustrating the application of these guidelines in urological practice
  5. Analyze breakthrough treatments in the management of advanced and metastatic hormone naïve prostate cancer
Course summary
Available credit: 
  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Non-Physician Participation
Course opens: 
Course expires: 

Education Council Disclosures

 Education Council Disclosures 2021

COI Review Work Group Disclosures

 COI Review Work Group Disclosures 2021

All relevant financial relationships have been mitigated. 

AUA Office of Education Staff has nothing to disclose.

Course Director(s)

Michael Cookson, MD,MHA

has a financial relationship (Consultant or Advisor (Oncology)) with Bayer Healthcare Pharmaceuticals;.
has a financial relationship (Consultant or Advisor (Specialty Not Specified)) with TesoRx Pharma LLC;.
has a financial relationship (Consultant or Advisor (Oncology)) with Merck;.
has a financial relationship (Consultant or Advisor (Oncology)) with Astellas Pharma, Inc.;.
has a financial relationship (Consultant or Advisor (Oncology)) with Myovant Sciences;.

David Jarrard, MD

has no relevant financial relationships to disclose at this time.

Adam Kibel, MD

has a financial relationship (Consultant or Advisor (Oncology)) with Bayer;.
has a financial relationship (Consultant or Advisor (Specialty Not Specified)) with Insight Diagnositics;.
has a financial relationship (Consultant or Advisor (Oncology)) with AstraZeneca;.
has a financial relationship (Consultant or Advisor (Specialty Not Specified)) with Merck;.
has a financial relationship (Consultant or Advisor (Specialty Not Specified)) with Profound;.
has a financial relationship (Other (Oncology)) with advantagene;.
has a financial relationship (Consultant or Advisor (Specialty Not Specified)) with Janssen;.
has a financial relationship (Consultant or Advisor (Oncology)) with General Electric;.
has a financial relationship (Other (Specialty Not Specified)) with Bristol-Myers Squibb;.

William Lowrance, MD, MPH, MBA

has a financial relationship (Scientific Study or Trial (Specialty Not Specified)) with Myriad Genetics;.
has a financial relationship (Investment Interest (Specialty Not Specified)) with Stream Dx;.


Learners will participate in this online educational activity by taking the pretest, viewing the webcast and completing the posttest and evaluation. To claim CME credit for this enduring material, learners must complete the posttest, passing with 80% accuracy and submit the program evaluation.

Estimated time to complete this activity: 2.00 hours

Release Date: September, 2021
Expiration Date: September, 2022


The American Urological Association (AUA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


The American Urological Association designates this enduring material for a maximum of 2.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


The AUA is not accredited to offer credit to participants who are not MDs or DOs. However, the AUA will issue documentation of participation that states that the activity was certified for AMA PRA Category 1 Credit™.


It is the policy of the AUA to ensure that the content contained in this CME activity is valid, fair, balanced, scientifically rigorous, and free of commercial bias.


All persons in a position to control the content of an educational activity (i.e., activity planners, presenters, authors) are required to disclose to the provider any relevant financial relationships with any commercial interest. The AUA must determine if the individual’s relationships may influence the educational content and resolve any conflicts of interest prior to the commencement of the educational activity. The intent of this disclosure is not to prevent individuals with relevant financial relationships from participating, but rather to provide learners information with which they can make their own judgments.


All disclosures will be reviewed by the program/course directors or editors for identification of conflicts of interest. Peer reviewers, working with the program directors and/or editors, will document the mechanism(s) for management and resolution of the conflict of interest and final approval of the activity will be documented prior to implementation. Any of the mechanisms below can/will be used to resolve conflict of interest:

  • Peer review for valid, evidence-based content of all materials associated with an educational activity by the course/program director, editor, and/or Education Content Review Committee or its subgroup.
  • Limit content to evidence with no recommendations
  • Introduction of a debate format with an unbiased moderator (point-counterpoint)
  • Inclusion of moderated panel discussion
  • Publication of a parallel or rebuttal article for an article that is felt to be biased
  • Limit equipment representatives to providing logistics and operation support only in procedural demonstrations
  • Divestiture of the relationship by faculty


The audience is advised that this continuing medical education activity may contain reference(s) to off-label or unapproved uses of drugs or devices. Please consult the prescribing information for full disclosure of approved uses.

Available Credit

  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Non-Physician Participation
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