Matthew Cooperberg graduated from Dartmouth College, where he finished summa cum laude with a major in English. He earned his MD and MPH degrees at Yale University, and completed residency in Urology and fellowship in Urologic Oncology at UCSF. At the end of his training, Dr. Cooperberg joined the faculty at UCSF. He is Chief of Urology at the San Francisco VA Medical Center, and he maintains busy clinical practices both there and at the UCSF Helen Diller Family Comprehensive Cancer Center, where is the Urology co-Leader of the Prostate Program. He also holds a secondary appointment in the Department of Epidemiology & Biostatistics.

He is actively engaged in research approaching the challenges of prostate cancer from many interrelated angles, from molecular analyses to health system-wide research. He has written or contributed to over 400 research articles. Early in 2013 Dr. Cooperberg co-authored a proposal for a national urology registry which served as the basis for the AUA Quality (AQUA) Registry, a project for which he now serves as Senior Physician Advisor. In 2015 he won the AUA Gold Cystoscope Award, and in 2016 was awarded his first R01 grant as Principle Investigator from the National Cancer Institute, to develop and validate novel miRNA-based biomarker signatures for refined prostate cancer prognosis.

He lives in San Francisco with his wife, Jacqueline Dolev (a derm­atologist and fellow Yale Medical School alum), where they work primarily to keep up with their children, Jake and Sarah.