Dr. Castle is Professor of Urology at Mayo Clinic College of Medicine. His surgical expertise includes minimally invasive urologic oncology including robot-assisted radical cystectomy, prostatectomy, retroperitoneal lymph node dissection, and partial nephrectomy. He has performed many of these procedures as demonstrations internationally as he pioneered robot cystectomy as well as robot RPLND as the first to develop the approach. He is also the director of the international laparoscopic nephrectomy courses throughout Mexico on behalf of the American Urologic Association and has served on several committees and guidelines panels within the American Urologic Association. He also serves on the Early Detection of Prostate Cancer panel for the National Comprehensive Cancer Network (NCCN). Dr. Castle's research interests include prostate cancer, bladder cancer and kidney cancer. He is the director of the Desert Mountain CARE Prostate Cancer Research Fund and is the principal investigator of his lab housed at the Mayo Clinic Collaborative Research Building. His basic science research is focused on novel secondary hormonal therapies of prostate cancer and apoptotic pathways related to manipulations of the androgen and estrogen receptors. In addition, genomics of prostate and bladder cancer as well as inflammatory mediators of intravesical therapy of bladder cancer are studied in his lab. He also directs the prospectively collected genitourinary biorepository at Mayo Clinic Arizona that houses over 40,000 specimens.