V04-07: How to improve your Xiapex results in Peyronie’s disease: The Percutaneous Needle Tunnelling (PNT) technique. Step-by-step surgical video
Intralesional injection of collagenase from Clostridium histolyticum (CCH; Xiapex®) has demonstrated an improvement in curvature in selected patients, sparing many of them from surgery. A combination of two techniques for the treatment of Peyronie’s disease (PD): percutaneous needle tunnelling (PNT) on the plaque and subsequent administration of CCH has been used in our centre since December 2016. We believe this combination could lead to a more cost-effective treatment. In this video we will show how this technique is performed in our centre.
Our modified IMPRESS-based protocol consisted of two collagenase injections, at one-week intervals, followed by penile modelling. Patients used penile traction therapy, tadalafil and pentoxifylline for the next two months. Before the injection of Xiapex®, PNT was performed by creating multiple tunnels or holes along the entire plaque using a 25G needle.
Thirty-two patients with stable disease (curvature