Comparative Analysis Of The Natural History Of De Novo Peyronie’s Disease Versus Post-Radical Prostatectomy Peyronie’s Disease


It has been estimated that the minority of men with PD when left untreated improve their deformity and that approximately half of them will worsen their deformity over the same period. PD appears to be associated with RP. Little is understood about how RP-associated PD (RPD) differs from de novo PD (DPD). This study was undertaken to compare the natural history of this condition between men with RPD and DPD.


Consecutive patients developing RPD within 2 years of their operation and patients with DPD who opted to not pursue any treatment had demographic, comorbidity, and PD characteristics recorded. All patients had an in-office curvature assessment (CA) and a penile duplex Doppler ultrasound (PDDU) at baseline and a repeat CA at least 12 months after being initially evaluated.


146 men with RPD and 246 men with DPD were included for analysis. Mean age was RPD 62±16 vs 52±22 years (p


There was no clear difference in the natural history of PD in men after radical prostatectomy compared to men with de novo PD. RPD patients were more likely to have shorter SFPL and a lower incidence of diabetes.

Funding: NONE