Tumor Enucleation: Functional Comparison with Standard Partial Nephrectomy

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Tumor enucleation (TE) optimizes parenchymal preservation and could yield better function than standard partial nephrectomy (SPN). However, data about this are controversial. Our study compares functional outcomes for TE and SPN strategies.


Patients managed with partial nephrectomy (PN) with necessary data for analysis of preservation of ipsilateral parenchymal mass and global GFR from two centers were included. All studies were required


Analysis included 71 TE and 373 SPN. Median preoperative global GFR was comparable for TE and SPN (75mL/min/1.73m2 versus 78mL/min/1.73m2, p=0.6). Median tumor size was 3.0cm for TE and 3.3cm for SPN (p=0.03). Median R.E.N.A.L scores were 7 in both cohorts. For TE, warm and zero ischemia were used in 51% and 49%, respectively. For SPN, warm and cold ischemia were used in 72% and 28%, respectively. Capsular closure was performed in 46% of TE and 100% of SPN (p


Our analysis suggests that TE has potential to maximally preserve parenchymal mass compared to SPN and may provide optimized functional recovery. Further investigation will be required to evaluate the clinical significance of these findings.

Funding: none