Serum Vitamin D Status, Vitamin D3 Supplementation and Urine Calcium Levels Among 140 Calcium Kidney Stone Patients

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Although there are current guidelines for the metabolic evaluation of patients with nephrolithiasis, there is no guideline for the management of coexisting vitamin D deficiency among these patients. The available research is not clear regarding the role of vitamin D in either causation of, or protection from, kidney stone formation. It is known that vitamin D has an essential role in calcium metabolism, and that vitamin D deficiency is common in the population. The purpose of this research is to help clarify the association, if any, between vitamin D status and urine calcium levels among patients with calcium kidney stones.


This study detected and treated vitamin D insufficiency in calcium kidney stone patients with concurrent metabolic urine studies before and after vitamin D supplementation. Between 2015 and 2017, 140 patients were evaluated in a community based urology practice following management of an acute episode of nephrolithiasis. Only patients with calcium composition stones were included. Initial metabolic evaluation measured stone composition, serum chemistry, 24 hour urine chemistry and baseline serum 25-hydroxy vitamin D (25-OHD). Patients who were found to be "not sufficient" for 25-OHD (