Active surveillance in young prostate cancer patients: From the PRIAS-JAPAN study
We assessed the state of younger AS patients from the analysis Japanese cohort(PRIAS-JAPAN) forming part of the Prostate Cancer Research International: Active Surveillance (PRIAS) study.
PRIAS-JAPAN started in January 2010. 37 institutions are participating in this study, and the Institutional Review Boards of the participating centers have approved the study protocol. The inclusion criteria for the PRIAS study are as follows: clinical stage T1c/T2, PSA ? 10 ng/ml, PSA density (PSAD)
Until September 2017, 768 patients were enrolled and 96 were in young group at enrollment. Patients back ground of young group was as follows: Median age was 56, median PSA was 4.9ng/ml. One positive core was in 73 and two positive cores were in 23. T1c were in 92 and T2a were in 4. At enrollment, the prostate volume of young group was significantly smaller than that of older group. However, there is a not significant difference between both group in PSA value and pathological factors. Re-biopsy rate of young group is lower than that of aged group at 1 year?young group vs aged group; 59? vs 77%?and 4 year?39? vs 47%?. Although Re-classification rate of 1st re-biopsy is lower in young group(16.3% vs27.7%), that of 2nd re-biopsy was the equivalent of the value in both group?20% vs 22.5%?. After one year and five years, both group shows similar AS remaining rate (one year; 84.2vs 85.7%, five years; 42.2 vs 51.7%). 24 patients of young group selected definitive therapy and surgery was the most frequently chosen treatment option.
There is a not significant difference between both group in AS remaining rate. Younger patients tend to avoid re-biopsy but to choose surgery as a definitive therapy.