MP08-09: Transurethral denudation of the bladder mu ... e: shedding new light on an old technique. (AM - 2018)

Transurethral denudation of the bladder mucosa by a needle electrode: shedding new light on an old technique.

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Although the procedure of denudation of the bladder mucosa was developed over 50 years to treat patients with low-grade non-muscle invasive bladder cancer, this technique was almost abandoned because of several reasons. The procedure was usually performed by open surgery. Serious complications, including severe bladder hemorrhage, urinary extravasation, bladder contracture, and hydronephrosis occurred post-operation. Recently, needle electrode proved to be a useful tool in transurethral resection. In this study, 6 cases with multiple non-muscle invasive bladder papillomas were treated with transurethral mucosal denudation by using a needle electrode.


The patients underwent transurethral bladder mucosa denudation under general anesthesia by using a needle electrode. The edge of the mucosa planned to be stripped was marked by electrocautery with the needle tip. Then the needle was stabbed into the submucosal layer and the mucosa was stretched away from the bladder wall, followed by cutting with the electroresection current. Blunt dissection with the needle electrode was performed in the submucosal space. Electrical energy during denudation was not used unless bleeding occurred. Precise electrocoagulation on the bleeding point was performed by the tip of the needle. The peri-orifice mucosa as well as triangle mucosa was retained.


All the patients underwent transurethral extensive or partial mucosal denudation (more than 1/3 of the bladder mucosa). The mean denudation time was 42±17 minutes. Total blood loss was less than 2 ml in every case. No bladder perforation or obturator nerve reflex occurred. Postoperative bladder irrigation was not performed. The Foley catheter was removed 10-12 days post-operation. Frequency or urgency occurred in all the patients after catheter removal, but the bladder volume recovered to 312±82ml 8 weeks post-operation. Regeneration of the mucosa took place within 12 weeks as normal urothelium. Specifically, we encountered no hemorrhage, urinary extravasation, bladder contracture, or hydronephrosis during a mean follow-up of 10 months. One patient had tumor recurrence on the residual mucosa at 3 months and received a TURBT.


Transurethral mucosal denudation by this novel technique could be performed simply and safely. Complications could presumably be reduced by limiting the operation to subtotal or partial stripping, and by blunt denudation without electrical energy. In addition, the peri-orifice mucosa and triangle mucosa were retained which would facilitate the mucosa regeneration.

Funding: none