Anastrazole is an Effective Treatment for Infertile Men with Hyperestrogenemia

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INTRODUCTION

Male infertility has multiple etiologies, many of which are treatable. Recent reports have demonstrated the deleterious impact of obesity on male fertility. Obese men often experience hypogonadism, typically secondary to hyperestrogenemia. This is presumably due to increased aromatase activity in body fat, resulting in impaired hormone and sperm production. The aim of this study is to investigate the effect of anastrazole on semen profiles in infertile men with hyperestrogenemia.

METHODS

Following IRB approval, we retrospectively evaluated all patients seen at a single academic Reproductive Medicine Center from January 2011 to June 2016 for infertility related to hyperestrogenemia. Patients included in this study demonstrated either true (Estradiol >42pg/mL) or relative (defined as Testosterone: Estradiol ratios 50% increase in total progressively motile sperm counts (p=0.02).

CONCLUSION

Anastrazole therapy can significantly improve semen quality in infertile men with hyperestrogenemia.

Funding: none